Low-dimensional clustering detects incipient dominant influenza strain clusters
Identifieur interne : 000086 ( 1957/Analysis ); précédent : 000085; suivant : 000087Low-dimensional clustering detects incipient dominant influenza strain clusters
Auteurs : Jiankui He ; Michael W. Deem [États-Unis]Source :
- Protein Engineering, Design & Selection [ 1741-0126 ] ; 2010.
Descripteurs français
- KwdFr :
- Algorithmes, Analyse de regroupements, Biologie informatique, Flambées de maladies, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Modèles biologiques, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (), Sous-type H3N2 du virus de la grippe A (génétique), Évolution moléculaire.
- MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- métabolisme : Glycoprotéine hémagglutinine du virus influenza.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- Algorithmes, Analyse de regroupements, Biologie informatique, Flambées de maladies, Humains, Modèles biologiques, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Évolution moléculaire.
English descriptors
- KwdEn :
- Algorithms, Cluster Analysis, Computational Biology, Disease Outbreaks, Evolution, Molecular, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans, Influenza A Virus, H1N1 Subtype (chemistry), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H3N2 Subtype (chemistry), Influenza A Virus, H3N2 Subtype (genetics), Influenza, Human (epidemiology), Influenza, Human (virology), Models, Biological.
- MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus.
- chemistry : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype.
- virology : Influenza, Human.
- Algorithms, Cluster Analysis, Computational Biology, Disease Outbreaks, Evolution, Molecular, Humans, Models, Biological.
Abstract
Influenza has been circulating in the human population and has caused three pandemics in the last century (1918 H1N1, 1957 H2N2 and 1968 H3N2). The 2009 A(H1N1) was classified by World Health Organization as the fourth pandemic. Influenza has a high evolution rate, which makes vaccine design challenging. We here consider an approach for early detection of new dominant strains. By clustering the 2009 A(H1N1) sequence data, we found two main clusters. We then define a metric to detect the emergence of dominant strains. We show on historical H3N2 data that this method is able to identify a cluster around an incipient dominant strain before it becomes dominant. For example, for H3N2 as of 30 March 2009, the method detects the cluster for the new A/British Columbia/RV1222/2009 strain. This strain detection tool would appear to be useful for annual influenza vaccine selection.
Url:
- https://api.istex.fr/ark:/67375/HXZ-NW4S730W-W/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978544
DOI: 10.1093/protein/gzq078
Affiliations:
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ISTEX:8EC35380DDBAC63CF67D8CA006DDBA5484E41EC6Le document en format XML
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The 2009 A(H1N1) was classified by World Health Organization as the fourth pandemic. Influenza has a high evolution rate, which makes vaccine design challenging. We here consider an approach for early detection of new dominant strains. By clustering the 2009 A(H1N1) sequence data, we found two main clusters. We then define a metric to detect the emergence of dominant strains. We show on historical H3N2 data that this method is able to identify a cluster around an incipient dominant strain before it becomes dominant. For example, for H3N2 as of 30 March 2009, the method detects the cluster for the new A/British Columbia/RV1222/2009 strain. This strain detection tool would appear to be useful for annual influenza vaccine selection.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><noCountry><name sortKey="He, Jiankui" sort="He, Jiankui" uniqKey="He J" first="Jiankui" last="He">Jiankui He</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Deem, Michael W" sort="Deem, Michael W" uniqKey="Deem M" first="Michael W." last="Deem">Michael W. Deem</name></region><name sortKey="Deem, Michael W" sort="Deem, Michael W" uniqKey="Deem M" first="Michael W." last="Deem">Michael W. Deem</name><name sortKey="Deem, Michael W" sort="Deem, Michael W" uniqKey="Deem M" first="Michael W." last="Deem">Michael W. Deem</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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